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GLP-1s can be life-changing, but they also demand a clear strategy: Whats your definition of ROI retention, productivity, or pure cost reduction

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GLP-1 has been reported to act on neural pathways by acting on areas of the brain with a weak blood brain barrier [18,19,20] and vagal afferent [21,22,23]

Comp Biochem Physiol C Toxicol Pharmacol 154:146153 Ashour AE, Abdel-Hamied HE, Korashy HM, Al-Shabanah OA, Abd-Allah ARA (2011) Alpha-lipoic acid rebalances redox and immune-testicular milieu in septic rats

In studies of people with type 2 diabetes inadequately controlled on basal insulin or GLP-1 RA, switching to a fixed-ratio combination of basal insulin and GLP-1 RA demonstrated significant improvements in blood glucose levels and achievement of glycaemic goals with fewer hypoglycaemic events than with basal insulin alone [216,217,218,219,220]