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Optimizing the substituent on the benzimidazole nitrogen proved a fruitful approach to improve potency without detrimentally impacting physiochemical properties, with smaller, more polar groups preferred
It peaks during the first 1-2 weeks at each new dose level and typically resolves within 4-8 weeks as receptor adaptation occurs
By changing how the brain perceives food, these medications can make it easier to change behavior and maintain healthier choices
The key difference between medication-related changes and IBS flares is that medication-induced symptoms typically peak in weeks 1-3 and improve with dose titration, whereas IBS symptoms fluctuate based on triggers like stress, food sensitivities, and gut microbiota shifts
Vitali G, Parente R, Melotti C
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