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In another experiment, R3G and R4G upregulated SIRT-1 mRNA by 22.7 17.9% and 22.8 16.9% respectively, showing anti-inflammatory properties 61

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They can restructure ECM and regulate ECM components by degrading ECM via producing MMPs, serine proteases and cathepsins (Ruffell et al., 2012), which may facilitate tumor cell migration, invasion and metastasis

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