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Because the phenotype associated with MC1R mutation is self-evident, identification of these individuals with potentially altered nociceptive sensitivity, and perhaps anaesthetic efficacy, is easy (at the expense of making blinded trials difficult)
National Institute for Biological Standards and Control
Further studies have demonstrated that the inhibition of NO production can mimic the effects of antidepressants (Ghasemi, 2019)
5-HT2 receptor regulation of mitochondrial genes: unexpected pharmacological effects of agonists and antagonists
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