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How GLP-1 RAs affect appetite Within the gastrointestinal tract, GLP-1 RAs delay gastric emptying, thereby sustaining mechanical fullness signals through vagus nerve activity
40 , Springer Nature Limited
Mechanistically, an in vitro study found that exendin-4 inhibited the secretion of IL-1 and TNF- from mouse colonic smooth muscle cells (CSMCs) via the pathway mediated by cAMP and NF-B, thereby exerting anti-inflammatory effects [218]
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