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Adipocyte-specific inactivation of NAMPT, a key NAD(+) biosynthetic enzyme, causes a [PMID: 38809511] Laboratory literature summary: Adipocyte-specific inactivation of NAMPT, a key NAD(+) biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in research
Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles
For a 200-pound individual, this equates to approximately 146 g per dose
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