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Clinicians who treat these patients must be willing to move beyond a pharmacotherapy-first approach and embrace the multimodal framework that the complexity of this problem demands
Shortly after gastrulation, molecular cues including fibroblast growth factor (FGF) signaling originating from the mesendoderm and the hindbrain instruct the preplacodal field surrounding the neural plate to form a patch of Pax2 -expressing ectoderm, which constitutes the otic-epibranchial placodes (Noramly and Grainger, 2002
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