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Recommendations for the peri-operative management of patients taking sodium-glucose cotransporter-2 inhibitors [1] : The risk of peri-operative ketoacidosis and mitigation strategies should be discussed with the patient using a shared decision-making approach." "Sodium-glucose cotransporter-2 inhibitors should be omitted the day before and the day of a procedure

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However, these adverse effects have been described as mild, with PubMed researchers concluding that berberine is a safe medicinal plant. Furthermore, no serious side effects were reported from berberine use in a study involving 2,569 patients (33)

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