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Decrease in lines of expression such as those on the forehead, perioculars and nasogenic groove

Large-scale human trials evaluating lifespan, disease prevention, or long-term aging outcomes do not currently exist

Ongoing and Future Research Directions Current research directions focus on mechanistic understanding of BPC-157's cellular and molecular effects

SCFAs (C2-C4) can potentiate CD8 T-cell metabolism and dendritic-cell competence, enhancing antiPD-1 responses in defined settings [90,91,92], yet systemic SCFAs can blunt CTLA-4 blockade, curb NK-cell effector function, or favor myeloid immunosuppression via FFAR2 MDSCs [53, 89, 103]

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