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GLP-1 prevents neurodegeneration via upregulation of GLUT, thus reducing the potential for glutamate excitotoxicity

The increased bulk can help counteract the slowed transit time associated with GLP-1 medications causing constipation

If gastrointestinal side effects are prominent, oral rehydration solutions may be beneficial

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We further show that RGDV activates the Pns11-Pelo complex to compete with E3 for binding to Pelo, thereby suppressing the E3-mediated ubiquitinated degradation of the Pelo-Hbs1 complex