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NICE guidance on obesity pharmacotherapy is based on robust, peer-reviewed evidence from completed trial programmes, and retatrutide has not yet reached that threshold

A new Aon study of 50 million covered lives found that after year one, medical spend growth for GLP-1 users fell to half that of peers, and hospitalizations for major cardiovascular events dropped 44% within two years

However, its important to note that at this stage, GLP-1 RAs should not be thought of as a cure for arthrofibrosis (or any form of fibrosis)

Even so, Nelson and colleagues did not utilize a placebo controlled, double-blinded design [15], which limits their findings