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Ashrafian et al., 2019)
Ozempic reduced the annual rate of change in eGFR 1 For adults with T2D and CKD for a confirmatory secondary endpoint: observed mean change in eGFR over time (the annual rate of change in eGFR) vs placebo when both were added to standard of care 1,2 Observed mean plot: eGFR (mL/min/1.73 m 2 ) by week in FLOW trial 1,2,ff ff Observed data from the in-trial period until Week 104
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As underlying mechanisms, it has been reported that GLP-1 causes renal vasodilatation, increases renal blood flow, increases glomerular filtration rate, inhibits the Na + /H + exchanger 3 in proximal tubule and decreases sodium, bicarbonate and water reabsorption [12, 14]
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