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The glutamate-cysteine ligase catalytic subunit (Gcl-c), the main controlling step of GSH synthesis is less expressed in mice overexpressing PGC-1 at basal conditions
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Its half-life of approximately two hours in rodent models longer than GHRP-6 due to its approximately five-fold lower systemic plasma clearance produces GH pulses of meaningful duration while preserving the inter-pulse intervals that allow natural somatostatin feedback to operate
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