The reason they are interesting for PMOS is simple: many women with PMOS have insulin resistance
GLP-1 has a variety of effects, originating from the presence of its receptors in specific nuclei of the lung, pancreas, gastrointestinal tract, kidney, heart, bone, central nervous system, etc
Pinto RE, Bartley W
Additionally, it regulates matrix metalloproteinases (MMPs), ensuring balanced degradation of damaged structural proteins alongside newly synthesized matrix assembly
Substrates to BCRP include (Table 1): chemotherapy agents (mitoxantrone, camptothecins, tyrosine kinase inhibitors), antivirals (zidovudine, lamivudine), HMG-CoA reductase inhibitors (statins), benzimidazoles, and antibiotics (ciprofloxacin, rifampicin) (Bailey et al