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These predispositions don't dictate your dose, but they provide clinical context for why some patients tolerate higher doses while others experience side effects at standard doses

3328-A THE HIGHER RISK OF LIVER CIRRHOSIS IN PI*MZ SERPINA1 CARRIERS IS NOT CAUSED BY THE PRESENCE OF A DIFFERENT PRECIPITATING MUTATION Sona Frankova 1 , Zuzana Rabekova 2 , Magdalena Nerolodova 2 , Ondrej Fabian 2 , Martin Kveton 2 , Milan Jirsa 2 and Jan Sperl 1 , (1)Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, (2)Institute for Clinical and Experimental Medicine Background: The homozygous carriage of the mutated Z allele at the rs28929474 locus in the SERPINA1 alpha-1-antitrypsin (AAT) gene leads to pulmonary emphysema and liver cirrhosis

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