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Likewise, in the case of TNBC, immune-related processes such as interferon signaling and antigen presentation have been observed (285), laying the groundwork for ongoing immunotherapy
Additionally, C11-BODIPY staining indicated that GCLC overexpression restored lipid peroxidation levels in cells expressing shACTL6A, phenotypes remained significant when treated with erastin and was reversed by Fer-1 (Fig
Disruption of cysteine uptake and collapse of intracellular GSH pool induces an inhibition of the detoxifying activity of GPx4 and excessive accumulation of oxidatively damaged lipids at the membrane, although it remains unclear if this solely affects the cell plasma membrane, or the effect also extends to organelle membranes
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