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Orforglipron, like all GLP-1 therapies, works best when conceptualized as a long-term or indefinite treatment rather than a temporary intervention, similar to how blood pressure medications manage hypertension without "curing" it
"Pregnancy or intention to become pregnant were exclusion criteria in our trials with semaglutide in both obesity and type 2 diabetes
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What happens after stopping a GLP-1 varies by person and depends largely on the underlying metabolic or lifestyle drivers behind their weight
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