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The Th17 marker gene Rort and the Th1 and Th2 regulatory genes Tbet and Gata3 were also significantly elevated, accompanied by a significant increase in various systemic inflammation-related genes such as interferon gamma ( IFN- ), etc (88)
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In severe cases, this can lead to dehydration and acute kidney injury, particularly in vulnerable patients
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"It needs to become a national issue
KPV's mechanism of action (NF-kB inhibition) overlaps with some conventional autoimmune drugs, particularly corticosteroids and JAK inhibitors, which also suppress NF-kB-mediated inflammation
