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Complementary or non-overlapping mechanisms
In preclinical data, the pair improves adipocyte NAD+ by inhibiting NNMT, resulting in better fat metabolism and reduced obesity.[8][3] For anti-aging, this translates to improved tissue resilience and reduced senescence
Rapamycin and Its Role in Longevity Huberman also delves into rapamycin, an mTOR (mechanistic target of rapamycin) inhibitor that has been shown to extend the lifespan of various animal models
In addition, dysregulated -KG flux from normal reductive anabolism via the TCA cycle toward R-2-HG production has been associated with other metabolic flux impairments and disrupted redox balance 119,120 (Fig
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