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Glutathione helps with skin lightening because it inhibits the enzyme tyrosinase, which is essential to the production of melanin, the pigment responsible for skin colour
EX-4 affects the microglia (immune cells in the brain) through an autocrine mechanism, in which interleukin-10 (IL-10) mediates -endorphin expression
It can also be used to find out whether your treatment is working well
Functional (primary) constipation is thought to involve gut-brain axis dysfunction (De Palma 2014)
Activation of POMC neurons leads to the release of alpha-melanocyte-stimulating hormone (-MSH), which subsequently binds to the melanocortin 4 receptor in the paraventricular nucleus of the hypothalamus and triggers appetite-inhibiting signaling cascade
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