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2 The circadian system, sleep, and their changes with aging This section outlines the fundamental organization of the circadian system and describes how circadian rhythms and sleep architecture are modified across the aging process

Arduini, A., Bonomini, M., Savica, V., Amato, A

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For example, when used in combination with certain antiepileptic drugs, it may lower the threshold for seizures and require adjustments to the dosage of antiepileptic drugs