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NbGSTU4 binds to the 3 untranslated region (UTR) of BaMV positive sense (+) RNA in a GSH-dependent manner and is necessary for efficient viral RNA replication i.e., production of a viral negative sense () RNA and then new genomic (+) RNA (Chen et al., in vivo BaMV replication and in vitro () RNA synthesis, while oxidative agents inhibit in vitro () RNA synthesis (Chen et al., Resistance-Inducing Symbiotic Microorganisms and Plant GSTs Non-pathogenic, symbiotic bacteria and fungi living in the rhizosphere of plants can be highly beneficial to plants attacked by pathogenic microorganisms

Advancing our understanding of how signaling pathways impact TJ assembly, disassembly, and permeability could accelerate novel therapeutic approaches aimed at restoring barrier integrity in conditions where it is compromised

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