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The potential mechanisms underlying the increased risk of gastric aspiration are not fully understood, and nowadays it is explained mainly by delayed gastric emptying and inhibition of gastrointestinal motor function that GLP-1-RAs exert through both central motor nuclei and vagal afferents [13, 14]

These lessons provide a critical framework for reassessing peptidereceptor systems that were historically abandoned or underexplored

PubMed Central (PMC) , Hodson, Leanne, et al

Differences in patient populations, trial duration, dose escalation, baseline weight, diabetes status, adherence, and estimand strategy limit direct comparisons

Like liraglutide, it is a GLP-1-only agonist