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Peto R, Davies C, Godwin J, Gray R, Pan HC, Clarke M, et al

They are recognized by PRRs [e.g., lipopolysaccharide (LPS) from Gram-negative bacteria (recognized by TLR4), flagellin (TLR5), lipoteichoic acid and peptidoglycan from Gram-positive bacteria (TLR2), viral nucleic acids, like double-stranded RNA (TLR3) and unmethylated CpG DNA (TLR9)], triggering the innate immune response

Role of the thioredoxin interacting protein in diabetic nephropathy and the mechanism of regulating NOD-like receptor protein 3 inflammatory corpuscle

Novel therapies in diabetic kidney disease and risk of hyperkalemia: a review of the evidence from clinical trials

Even with long term use, concerns of adverse effects are rarely reported