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Long-term human safety data for both peptides remains limited
The review proposes BPC-157 may have its own presence in synaptic vesicles, maintaining vesicle integrity and function while competing for receptor sites and substituting for neurotransmitters when neurons are damaged or depleted
It safeguards the brain parenchyma by preventing the entry of exogenous pathogens and neurotoxic plasma components
Historically, some nominations lacked sufficient safety, efficacy, or chemical characterization data, prompting nominators to withdraw them rather than face a definitive FDA ban
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