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John D Hayes, Jack U Flanagan, Ian R Jowsey 2005
Figure 4: Drug-Induced Liver Injury
The leading cause of CKD and ESRD is diabetes mellitus
Beyond GLP-1mediated effects, the gut-derived indole metabolite indole-3-propionic acid (IPA) has been shown to ameliorate PCOS in mice by restoring estrous cyclicity, improving insulin sensitivity, and reducing ovarian oxidative stress by activating the aryl hydrocarbon receptor (AhR) (26)
That does not mean it has no effect, but it does mean the evidence should be evaluated honestly rather than through clinic marketing
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