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a small retrospective study of 12 patients with chronic knee pain found 91.6% reported significant improvement after intra-articular injection, but this lacks a control group and has not been replicated Regulatory / legal status: Not FDA-approved for any medical use

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These results suggest that although the X(GD_L) proteases, including X(GD), are less catalytically active than wild-type BoNT/X protease and X(PC), they are more selective