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sponsored a 24-week, randomized, placebo-controlled obesity trial (N=536) testing oral AOD-9604 at doses of 1 mg, 5 mg, 10 mg, and 20 mg daily
All findings described here are from controlled preclinical research settings
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5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed
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