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Interestingly, direct injections of Ex-4 into the gustatory cortex of mice maintained on a high-fat diet reduced intake only when the fat density of the test diet differed from that of the maintenance diet, regardless of whether the shift was from high- to low-fat or low- to high-fat relative to the maintenance diet

However, some individuals may experience mild side effects such as gastrointestinal discomfort or nausea

This guide breaks down the science, compares both approaches, and gives you a practical framework to choose the timing that fits your lifestyle and goals

Instead, they prioritize foods that help maintain fullness and digestive balance

Extrinsic primary afferent signalling in the gut