Key takeaways Semaglutide titration starts at 0.25 mg weekly and increases every 4 weeks
This aligns with the majority of large-scale studies and meta-analyses, which indicate a reduction in the risk of depressive symptoms
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The headline On Thursday 21 May 2026, Eli Lilly announced that participants in TRIUMPH-1, the first Phase 3 trial of retatrutide in obesity, lost an average of 28.3% of their body weight at 80 weeks on the 12 mg dose, with 45.3% losing at least 30% of their starting weight [1]