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These neurons migrate over long distances to enter cortical and subcortical regions, playing crucial roles in maintaining the brains excitation/inhibition balance and regulating synaptic plasticity
The decreased expression of ATGL inhibits fatty acid mobilization of intracellular lipid droplets and promotes lipid droplet's aggregation, leading to renal tubular epithelial cell injury and renal fibrosis, and ultimately promotes the transformation of AKI to CKD[27]
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1 The primary outcome of interest for the trial was the percent change in body weight from baseline to week 72 with tirzepatide as compared with semaglutide
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