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de novo lipogenesis, along with downregulating enzymes linked to lipid synthesis, such as ACC and FAS ( in vitro experiment demonstrated that GLP-1RA induces the phosphorylation of Akt, PDK-1, and PKC-, which are key proteins involved in the insulin signaling pathway
was supported in part by a National Eye Institute Training Grant (grant no
These cell populations engage in a self-perpetuating cycle with their microenvironment: Inflammatory signaling induces senescence, which further amplifies microenvironmental inflammation and exacerbates hepatic dysfunction
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