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2011), leading to increased excretion and decreased absorption (Harper et al

[4] Endogenous GLP-1 is rapidly degraded primarily by dipeptidyl peptidase-4 (DPP-4), but also neutral endopeptidase 24.11 and renal clearance, resulting in a half-life of approximately 2 minutes

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Employers investing in these treatments expect meaningful outcomes, and success depends on more than prescriptions

A smaller subset of patients report mood changes in the other direction, including increased anxiety, emotional flatness, or depressive symptoms, particularly in the early weeks of treatment