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Mild side effects Mild side effects* of Vyvanse can include: insomnia (trouble sleeping) decreased appetite abdominal pain nausea and vomiting anxiety irritability feeling jittery dizziness dry mouth weight loss mood changes constipation diarrhea headache crashing (feeling tired or irritable as the effects of the drug wear off) Most of these side effects may go away within a few days or a couple of weeks

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The first few weeks brought some mild stomach discomfort, nothing compared to post-surgical recovery though

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