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A meta-analysis pooling data from two phase II and five phase III trials 195 confirmed that tirzepatide elicited greater HbA1c reductions than placebo, GLP-1RAs, and basal insulin

Mice lacking the CRF2 receptor exhibit a blunted response to the feeding-inhibitory effects of urocortin and selective CRF2 receptor antagonists block the suppressive effects of urocortins and CRF on food intake and body weight

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Post-menopausal women may respond more strongly to GH peptides due to lower baseline IGF-1 levels

Data are shown as mean SD