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Those who switched gained back about 14% of the weight they had lost, while those who stayed on tirzepatide lost a bit more around another 5.5%
Even after regaining weight, the participants who stopped tirzepatide were still about 10% below their original starting weight
Exenatide, on the other hand, should be avoided in patients with severe renal impairment (CrCl less than 30 mL/min)
On its own, it has demonstrated anti-tumor effects in rats, stopping tumor growth in 80% of cases (5)
Silencing of LS GLP-1R neurons increases food consumption and promotes obesity induced by high-fat food
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