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Orforglipron, Lilly's once-daily oral non-peptide GLP-1 agonist, helped overweight adults without diabetes lose 12.4% of their body weight over 72 weeks at the highest dose in a late-stage trial
Prior clinical trials assessing these medications for weight loss had limited scope and couldnt detect infrequent gastrointestinal issues
Why Protein Is Essential Protein supports: Lean muscle mass Metabolic rate Bone strength Immune function Hair, skin, and nail health Satiety and appetite control Without enough protein, weight loss may come from muscle rather than fat, increasing the likelihood of weight regain later
The potential for GLP-1 agonists to treat disorders like type-2 diabetes (T2D) was not lost on the endocrinology community (Reviewed here)
Increased lipid peroxidation and impaired enzymatic antioxidant defense mechanism in thyroid tissue with multinodular goiter and papillary carcinoma
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