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Real-world data from a 2025 study in Diabetes, Obesity and Metabolism which looked at actual clinical patients rather than trial participants showed tirzepatide patients lost 5.3% of body weight over six months compared to 2.7% with semaglutide
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Pregnancy and breastfeeding : do not start glutathione or NAC supplements without medical advice, as evidence for routine supplementation in these groups is limited (despite medicinal use of NAC for paracetamol overdose under specialist supervision)
Although 14 participants saw their BMI decline to 22 or lower, none met criteria for treatment discontinuation
R.AlhadeffA
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