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Within CBT models, such reductions are understood as a lowering of cue-reactivity and hedonic drive, two core maintaining mechanisms of overeating and binge-type behavior
Moreover, the magnitude of WL with retatrutide also exceeded that seen with other pipeline multi-agonists such as CagriSema (cagrilintide, an amylin agonist, in combination with semaglutide), mazdutide and survodutide (Fig
Cortisol, a major stress hormone, typically spikes alongside these other peptides but remains stable with ipamorelin
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