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doi: 10.1152/physiolgenomics.00119.2013 87 NascimentoK

L-carnitine shuttles long-chain fatty acids inside the mitochondria by forming a long chain acetylcarnitine ester

Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Cheng and Ristow, 2013), steroid hormone biosynthesis, removal of ammonia, integration of metabolic and signaling pathways for cell death and autophagy (Hammerman et al., 2004

Accordingly, HDAC inhibitors have been shown to induce specific changes in gene expression and influence growth arrest, differentiation, cytotoxicity and induction of apoptosis (50)

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