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Nonetheless, there remains an ongoing need for additional medicines, particularly those with a distinct mode of action that could be used independently or in combination with the current incretin-based therapeutics

The caveat: these effects have not been replicated in human subjects, and the dosing required to achieve therapeutic CNS concentrations in humans remains undefined

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The concentration of Human KLK10 in the samples is then determined by comparing the OD of the samples to the standard curve