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In conclusion, the intricate interplay between metabolic diseases and protein homeostasis underscores the pivotal role of proteostasis networks, including the UPS, autophagy, and the UPR, in the pathogenesis of conditions such as obesity, T2DM, and MASLD (Fig
63 One prevalent mechanism is the disruption of tumor antigen presentation
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10.1038/s41568-020-0273-y 142 LeoneR
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