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doi: 10.1001/jamainternmed.2025.1794 54 MehrtashFDushayJMansonJE

For individuals struggling with weight management, brand-name prescription drugs like Saxenda and Ozempic have emerged as effective options

Preclinical research demonstrated that NNMT inhibition with 5-Amino-1MQ reduced white adipose tissue mass by ~35% , shrank adipocyte size by 30-40%, and lowered plasma cholesterol by ~30% all without affecting food intake