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Anti-obesity drugs should be offered as initial treatment of overweight and obesity for adults with weight-related comorbidities and for those at high risk of complications, and as a component of first-line treatment for patients with obesity and overweight without comorbidities
2018;125(3):e5466
Silencing of TGF-1 in tumor cells impacts MMP-9 in tumor microenvironment
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In addition, the activity of PDH is also downregulated by nitro oxide (NO) by directly affecting its PDH-E3 via S-nitrosation, which is independent of HIF-1 (137)
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