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Together, these preclinical findings strongly indicate that ferroptosis is not a secondary consequence of neurodegeneration in AD, but rather functions as an upstream pathogenic mechanism that drives A production, tau hyperphosphorylation, and neuronal apoptosis

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The pH titration experiments were performed in 100 mM HEPES, 150 mM NaCl 2 , 0.5 mM MgCl 2 and pH between 6 and 9 adjusted by KOH, with the actual pH measured post-hoc

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International Journal of Endocrinology, 2018 , 4847376