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Mechanistically, cells use both extracellular and intracellular machinery to sense local nutrient and energy levels, followed by upregulation of corresponding nutrient receptors and transporters ( Lipids are high-energy compounds that produce more ATP per carbon molecule than glucose when fully catabolized ( Immunometabolism In some of the earliest studies on cellular metabolism, Warburg found that expanding tumor cells produced lactate from glucose, even in the presence of abundant oxygen, a process known as aerobic glycolysis ( in vitro use of aerobic glycolysis, particularly when T cells were stimulated through CD28 ( in vitro versus in vivo activation ( Fatty acid metabolism - an overview Fatty acid metabolism can be grossly divided into anabolic and catabolic processes

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