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From their beginnings as a treatment for type 2 diabetes, GLP-1 receptor agonists such as semaglutide and tirzepatide have seen an explosion in use, most popularly for weight loss

Mitochondrial GR is essential for: Protecting the electron transport chain components from oxidative damage Maintaining mitochondrial DNA integrity against oxidative lesions Supporting ATP production by preserving mitochondrial membrane potential Preventing mitochondrial-initiated apoptosis triggered by excessive oxidative stress Facilitating mitochondrial glutathione transport and utilization The mitochondrial glutathione system is particularly critical in neurons and other cells with high energy demands, where mitochondrial dysfunction can have catastrophic consequences

Moreover, the program is short-lived

128 The oncogene c-Myc upregulates Gln metabolism through transcriptional activation of GLS and SLC1A5 genes

Reports show that most abusers use the drug for its pharmacological properties, including sedation, stimulation, and anxiolytic effects