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Unlike Ozempic and Wegovy, which are solely glucagon-like peptide-1 (GLP-1) receptor agonists, or Mounjaro and Zepbound, which combine GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonism, retatrutide works by activating three key hormonal pathways

GLP-1 clinical guidance broadly recommends combining medication with lifestyle changes including physical activity to support results and minimize muscle loss

But they do acknowledge that the body has powerful signaling systems that shape appetite and energy use

Xiao H, Meng X, Songtao L, Li Z, Fang S, Wang Y, Li J, Tang J, Ma L