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Unlike a glitazone medication like Actos (pioglitazone), which improves insulin sensitivity, GLP-1 agonists do not mainly work by directly unlocking insulin resistance the way a sensitizer doesalthough weight loss from GLP-1 therapy can indirectly improve insulin sensitivity
Bonnet F, Scheen AJ (2017) Impact of glucose-lowering therapies on risk of stroke in type 2 diabetes
However, this evidence is derived from small observational studies and should be interpreted with caution
Your effective dose drops even though you are injecting the same amount
Alkem said it is also offering a reusable injection pen for higher maintenance doses, allowing patients to replace only the medication cartridge instead of buying a new device each time, a move aimed at reducing long-term treatment costs and improving adherence
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