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Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53

The severity of symptoms associated with fibroid, average blood loss and HRQL were also significantly improved with the use of green tea extract as compared to placebo, with no adverse effects identified ( Catechol-O-methyl transferase (COMT) is an enzyme expressed at a higher level in leiomyoma as compared to the normal myometrium ( In vitro study showed that the ability of green tea extract in inhibiting the proliferation of leiomyoma cells is in part due to the potential of EGCG in reducing the expression of the COMT enzyme ( in vivo study showed no impairment of EGCG on COMT activity and even increase by 24% after consumption of EGCG ( Decreased BCL-2 protein and elevated Bax protein expression are other mechanisms leading to apoptosis by EGCG ( The EGCG could have also exerted cell cycle arrest by causing a significant decrease in the expression of CDK4 and PCNA ( BMP2 gene appeared to have a 14-fold greater expression upon EGCG treatment on HuLM cells ( in vivo ( EGCG was also identified to differentially inhibit TNF- and LPS-mediated activation of NF-B ( Apart from producing promising effects, EGCG has several drawbacks, such as low stability, poor bioavailability, and highly metabolized under physiological conditions

10.1016/j.rvsc.2018.07.005 111 ZhangY.DongA.XieK.YuY

Thinking it might be worth a shot

Integrating chemical insights into the unique reactivity of persulfides and polysulfides with conventional HTS approaches should facilitate the development of more selective and efficient inhibitors and lead to a deeper understanding of RSS biology, as well as having the potential to provide novel therapeutic strategies for cancer, cardiovascular and metabolic diseases, and mitochondrial disorders in which RSS play a critical role